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Cho SS, Kim KM, Yang JH, Kim JY, Park SJ, Kim SJ, et al

Vitamin B12 (also known as cobalamin) is a water-soluble vitamin that plays an important role in metabolism, red blood cell formation, and nerve function

Another connection is that B6 is involved in the inflammatory signaling pathways in the lungs.[ref][ref][ref] Related article : Asthma, genetic variants, and IL33 inflammation Chronic Low Back Pain: A 2026 clinical trial found that a combination of B12, B1, and B6 was effective at reducing chronic low back pain

25 Case series and reports have described infants presenting with prolonged jaundice, acholic stools, and elevated direct bilirubin, consistent with cholestasis

B12 (cobalamin) is water-soluble

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