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Exclusion volumes primarily aim to boost specificity and selectivity of pharmacophore models by narrowing the search space, thereby minimizing false positives resulting from improper ligand positioning

Protein molecules are naturally attracted to these interfaces and can unfold (denature) when forced against them repeatedly

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Mateus FG, Moreira S, Martins AD, Oliveira PF, Alves MG, Pereira ML (2023) L-Carnitine and male fertility: Is supplementation beneficial