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The increase with amount smoked is also clearly evident when an alternative set of key values (1, 10, 20, 30, 40, 999) is used, though numbers of available RRs are quite sparse for the higher key values, when least-adjusted RRs are considered, and in both sexes (see Additional file 5: Detailed Analysis Tables)

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There is some evidence to suggest an increase in selection bias is unlikely to have greatly affected the findings, though it cannot be ruled out

These results have recently been confirmed in a quit snus use study (Gilljam et al., 2003)