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Considering the importance of GH and IGF-1 for brain functions and development, this apparent paradoxical protection may be explained by increased insulin sensitivity (40) and the prevention of age-related activation of the inflammasome and neuroinflammation (41, 42) observed in these mouse models (Figure 2)
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& Scherer, P
172 Wnt/-catenin pathway in liver disease The liver is a metabolic factory in humans
The cryo-EM maps and coordinates for the GluK2 in the intermediate state, deep-desensitized state 1, deep-desensitized state 2, and deep-desensitized state3 have been deposited in the EMDB under accession numbers EMD-48760, EMD-48759, EMD-48758, and EMD-48757, and in the PDB under accession codes, 9MZL, 9MZK, 9MZJ, and 9MZI, respectively