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No human trials on AOD-9604 for joint health have been published

Regulatory Toxicology and Pharmacology , 114 , 104665

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Considerations for Long-Term Users If you plan to use BPC-157 beyond a standard 46 week cycle, consider: Taking extended breaks between cycles Using the lowest effective dose Rotating injection sites to avoid local tissue fatigue or inflammation Monitoring subjective markers of progress and potential side effects (energy, GI symptoms, inflammation, blood pressure) Until clinical data becomes available, long-term safety remains uncertain so the guiding principle should be minimal effective use for specific, time-bound recovery goals

AOD-9604 has no appetite effects in either direction