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This collagen forms a part of the fibrils that anchor the basement membrane to the dermis, thereby providing structural stability and resistance to mild skin trauma.[137] A lack of type VII collagen often results in generalized skin blistering (starting at birth), skin atrophy, and scarring.[137] A registry of DEB pathogenic variants, The International DEB Patient Registry, is accessible on the internet.[138] An observational study analyzed individuals in the Dutch EB registry over a 30-year period

A 50% reduction in the Psoriasis Area and Severity Index (PASI 50) is a clinically significant endpoint in the assessment of psoriasis

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