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Vitale G., Salvioli S., and Franceschi C., Oxidative Stress and the Ageing Endocrine System, Nature Reviews Endocrinology 9, no

By selectively inhibiting NNMT , 5-Amino-1MQ can reduce the methylation of nicotinamide, leading to increased intracellular NAD availability and enhanced metabolic activity

[PubMed: 16757551] 60

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Further, 5-FU is also known to affect iron homeostasis, where 5-FU administration significantly raises Fe 2+ levels in vivo [30]

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