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Surprisingly, L-DKO mice did not die or significantly lose weight shortly after genetic deletion was induced (Fig

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Specifically, based on the content of Table 1, we learn that genomics and transcriptomics have not only identified genetic variations associated with OA but also revealed how these variations influence gene expression and their connection to the disease

The transcriptomic approach was done under these two conditions so that we would obtain an unbiased insight into (a) the possible pathways or proteins that were targets of 5-OP leading to their inactivation and consequently the effect on growth and (b) the cellular response to 5-OP toxicity enabling the cells to tackle the 5-OP treatment and accumulation