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If we go beyond this enormous significance of Complex 1 of the mitochondrial respiratory chain for Parkinsons and just look at what the main theory about how it happens in the first place, its a degeneration of the dopamine-based neurons in the basal ganglia that are controlling movement

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Ann Rev Nutr 2007

Neuron-specific STING knockout significantly attenuated neuronal damage in EAE mice

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It strengthens the mucosal barrier, which prevents harmful substances from leaking into the bloodstream