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Compared to anti-inflammatory peptides such as LL-37 or cathelicidins, BPC-157 does not display direct antimicrobial activity but modulates the immune-vascular axis in a more refined manner

Specifically, E14 Cagri adopts a downward rotamer to form hydrogen bonds and electrostatic interactions with R17 Cagri

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Mitochondrial dysfunction resulting from accumulation of trans-activation response element DNA binding protein 43 (TDP-43) increases the production of ROS, causing oxidative stress and establishing a vicious cycle that contributes to disease progression