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(2019) found that inhibiting canonical Wnt signal transduction in bone marrow stromal cells prevented the development of MDS and proposed that activation of -catenin signalling in the bone marrow of MDS patients may be a new treatment strategy that reduces -catenin levels or inhibits Wnt/-catenin signalling

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It targets a different appetite pathway than GLP-1 drugs, which is exactly why the combination works

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