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Le glutathion est synthtis en deux tapes dpendant de l'adnosine triphosphate : Tout d'abord, la gamma-glutamylcystine est synthtise partir de L-glutamate et de cystine par l'intermdiaire de l'enzyme gamma-glutamylcystine synthtase (galement connue sous le nom de glutamate-cystine ligase (GCL) ligase)

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