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Probing position N108, we found that incorporation of any other amino acid resulted in a substantially reduced formation of cyanidin ( 8 ) suggesting that the hydrogen-bond interaction of the asparagine to the flavonoid substrate is critical for dehydratase activity, while GSH-transferase activity was comparatively less affected for N108 variants comprising an alanine, histidine, tyrosine or tryptophan (Fig
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The authors concluded that, since the rate of postoperative side effects of fundoplication is low, while objective evidence of postoperatively de novo onset of GER occurred frequently, the addition of a fundoplication should be recommended during PEH repair
Physical Form: Lyophilized vs
