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Rifamycin antibiotics can impact birth control effectiveness In fact, only one type of antibiotic has been found to significantly interact with hormonal birth control: rifamycin antibiotics, which are used to treat tuberculosis

[10] [12] These interactions are supported by pharmacokinetic studies, clinical observations, and drug interaction databases

A 2026 review in Anais Brasileiros de Dermatologia found most local reactions are transient and resolve without dose adjustment

The short answer is a resounding yes

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