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Further investigations using elimination of the T-cell subsets and cytokine analyses revealed a protective role for the transforming growth factor--producing CD4(+) T cells in F11r(/) mice

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This, in turn, boosts metabolic rate and activates a gene known as sirtuin-1 (SIRT1), also referred to as the "longevity gene." SIRT1 is involved in reducing the risk of various conditions such as diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.

Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease

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