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Piyathilake CJ, Macaluso M, Chambers MM, Badiga S, Siddiqui NR, Bell WC, et al

Oxidative stress is a type of inflammation that occurs when an imbalance of antioxidants (like glutathione) and free radicals (molecules that cause rapid cell aging and death) starts attacking the body

Clinical Nutrition, 38(4), 1747-1755

So it became a question of seeing who made it and how it was made, to see if that shed any light on the matter

Surprisingly, very similar prediction results with AUROC = 0.80 was established in this external validation cohort, suggesting that these microbiome features can be used to distinguish and predict human TMAO producer phenotypes from carnitine metabolism and have adequate potential to be applied in different populations

They either occur naturally or are created in the lab