In agreement with our studies, immunohistological and electrophysiological evidence revealed reconstruction of the node of Ranvier in transplanted neonatal Shiverer mice and restoration of transcallosal conduction velocity (Windrem et al., 2008)
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These barriers are physically represented by the so-called tight junctions between brain endothelial cells and epithelial cells, attributed to the special proteins such as occludin, claudins, and the associated proteins zona occludens (ZO-1, ZO-2, and ZO-3), which are highly expressed in brain endothelium (Chen et al., 2009
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