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The clinical signs observed depend on the severity of intoxication, the degree of stress to which the animals are subjected and the time of observation after initial intoxication

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42 To investigate the role of Gpr15 in the effects of cigarette smoke exposure on immune function, Th17 and Treg cells were isolated from Gpr15 +/+ and Gpr15 / mice exposed to cigarette smoke

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It is possible that changes in diet may affect the vaginal microbiota through modulating the body's immune response to bacterial pathogenesis and/or through the interplay between the gastrointestinal and vaginal microbiomes (62, 63)