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Therefore, several issues need to be considered in future research: (i) Studies of animal models have made important contributions to our understanding of the pathophysiology of major depression, and more representative animal models of MDD should be developed

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A3: Research typically characterizes IGF-1 and its analogues, including IGF-1 LR3, as supporting hyperplasia (increased cell number) rather than direct hypertrophy (increased cell size)

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