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The regulation of the VHLHIF pathway is also related to iron metabolism and ferroptosis in ccRCC, as iron levels are significantly higher in RCC cells and the tumor microenvironment than in normal renal tissue (77), and as HIF-1 mediates the cellular upregulation of TfRC and heme oxygenase (HO) expression, promoting cellular iron accumulation (78, 79)

doi: 10.3390/molecules22060989 320 Walasek-JanuszMGrzegorczykAMalmANurzyska-WierdakRZalewskiD

In clinical populations, approaches combining cortical thickness (structural MRI), amyloid-PET, tau-PET, and white matter lesion burden may predict domain-specific cognitive decline with precision [601, 602]

4.2 Detailed expandable studies Study 1: Lau 2021, pivotal Phase 2 monotherapy Citation: Lau D.C.W., Erichsen L., Francisco A.M., et al

Molecular mimicry Molecular mimicry, also known as the cross-reactivity theory, is a phenomenon in which antigens from infectious agents share structural similarities with self-antigens

doi:10.1007/s40257-021-00595-7