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( i ) Confocal images of mitochondria (imaged by TOM20 staining) and mtDNA in cells treated with 5FU for 72 h

Since mitochondrial ROS are upstream activators of NLRP3 inflammasome and NF-kB pathways, reducing them at the source has downstream anti-inflammatory effects throughout the cell

Medically reviewed by Oghenefejiro Okifo | MD , Harvard Medical School | Henry Ford Hospital - Detroit, MI on October 29th, 2025

Studies measuring oxidative stress markers show consistent reductions in reactive oxygen species and improvements in antioxidant enzyme activity following peptide treatment

10.1088/0967-3334/17/4/004 Physiol Meas

Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial