Elimova E, Kim SM, Wang X, Shimodaira Y, Sohn BH, Skinner HD, Lee JH, Weston BR, Bhutani MS, Minsky B, Rice DC, Hwang JE, Swisher SG , Hofstetter W, Blum MA, Maru D, Ajani JA, Lee JS
How to Use: Pre-Workout: Take one serving of ProSupps L-Carnitine 3000mg before your workout to maximize fat burning and energy production.
This receptor specificity reduces stimulation of other pituitary axes that regulate cortisol, prolactin, or ACTH secretion
Sierra, A
Critically, these effects were achieved without food intake suppression, distinguishing MOTS-c from GLP-1 receptor agonists whose primary mechanism involves appetite reduction
Neurological Relevance Preclinical evidence suggests broader neuroprotective potential: In traumatic brain injury models, SS-31 reduced mitochondrial swelling, neuronal loss, and neuroinflammation Aged mice treated with SS-31 showed significantly improved exercise tolerance, muscle strength, and mitochondrial efficiency Studies demonstrate protection against ischemic injury and enhanced cardiac output Phase 3 trials are ongoing for dry age-related macular degeneration and primary mitochondrial myopathy (Stealth BioTherapeutics pipeline) Implications for Brain Aging Mitochondrial dysfunction is a hallmark of brain aging and neurodegeneration
