The intranasal route is particularly effective because it delivers the peptide directly to the brain through the olfactory mucosa, bypassing first-pass metabolism and the blood-brain barrier entirely
- A convenient way to maintain consistent intake
doi: 10.1016/j.bbamcr.2014.12.039 35 de CaboR.MattsonM
In this context, the aim of the present document is to summarize, in the form of a narrative literature review, the currently available data on the main mechanisms of action of GIP/GLP-1 co-agonists and the clinical effects of tirzepatide evaluated in various clinical trials
Accumulation of these compounds causes tissue damage through oxidative damage of cellular structures, that is, proteins, membrane lipids and nucleic acids (Reference Halliwell and Gutteridge44)
These adverse reactions can be lessened by carefully adjusting the dosage, reducing it as needed, or stopping the treatment altogether