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The current TNM staging criteria for esophageal adenocarcinoma are listed in Table 2.1

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Ann Clin Transl Neurol

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Mika, A., Minibayeva, F., Beckett, R

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Concurrently, unmetabolized fatty acids accumulate intracellularly, contributing to lipid overload and lipotoxicity [39]

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Together, these finding indicate that the toxic effects of DOX on the heart are strongly associated with iron overload and ferroptosis in mitochondria, indicating that targeting ferroptosis could serve as a promising therapeutic strategy for protecting the hearts of cancer patients from DOX-induced cardiomyopathy

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