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On the basis of these studies, the capacity of HGF to modulate neuro-inflammation is thus associated with an alteration in the balance of pro-inflammatory (Th1 and Th17) and anti-inflammatory (Th2 and Tregs) CD4 + T cells by influencing dendritic cell function

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GSH could be converted to its oxidized form, called glutathione disulfide, by glutathione peroxidase which decomposes ROS to H 2 O and O 2 , and the glutathione disulfide is then regenerated to GSH by glutathione reductase at the expense of NADPH [16, 17]

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Nat Rev Immunol 10(4):251267 Uddin MS, Mamun AA, Hossain MS, Akter F, Iqbal MA, Asaduzzaman M (2016) Neuroprotective potential of Phyllanthus emblica L

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