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Individual variation: Genetic differences in receptor density, metabolic clearance, and tissue repair capacity create significant individual variation

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In lactating cows, hindgut microbial-mediated secondary BAs metabolism was closely associated with plasma glucose and BHBA levels, mainly through remodeling taurine-conjugated and deconjugated BAs profiles to influence lipid absorption, suggesting the hindgut microbiotaBAs axis is critical for adapting to periparturient negative energy balance 85

Despite promising results in preclinical models and short-term human trials, several challenges must be addressed regarding these dietary interventions

Concomitant use of aspirin (or other nonsteroidal anti-inflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects

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