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138 IS is primarily associated with neuronal excitotoxicity, oxidative stress, neuroinflammation, apoptosis, mitochondrial damage, amyloid production, and tau protein dysfunction

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Alshaer W, Nsairat H, Lafi Z, Hourani OM, Al-Kadash A, Esawi E, et al

The extended dietary intake of metformin in mice has been found to decrease the expression of markers associated with oxidative damage in the liver (e.g., lysine-4-hydroxinonenal and 8-iso-PGF 2 ), correlating with a ~6% increase in overall lifespan and lower mean body weight [450]

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We have previously shown that Wnt /-catenin activation in the onychodermis contributes to the proliferation of the nail matrix epithelium and hair matrix via RSPO4 -mediated signaling 40