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Nicotine sickness (green tobacco sickness) is caused by a sudden stimulant spike

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Both of these shifts may be due to changes in cigarette design and composition, in how tobacco leaves are cured, and in how deeply smokers inhale cigarette smoke and the toxicants it contains (1, 8)

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Am J Epidemiol 152 : 3240 Janssen-Heijnen ML, Gatta G, Forman D, Capocaccia R, Coebergh JW (1998) Variation in survival of patients with lung cancer in Europe, 19851989