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If side effects become intolerable at any dose level, dropping back to the previous dose for two to four additional weeks before attempting escalation again often allows successful progression
There are no established safety concerns from the published literature at standard supplement doses in otherwise healthy adults
However, high supplemental doses of niacin may cause niacin flush, nausea, vomiting, stomach irritation and liver damage
Its important to maintain open communication with your healthcare team regarding any other medications you are taking, as well as any dietary changes
Antioxidants such as ascorbate (vitamin C), glutathione, coenzyme Q and vitamin E oxidize when they capture free radicals
Halaris, 2017), hypothalamic-pituitary-adrenal axis dysfunction (Gu et al., 2012), endothelial dysfunction (Chrysohoou et al., 2018
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