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While it can rapidly induce the expression and transcription of genes encoding antioxidant enzymes, including superoxide dismutase (Sod), catalase (Cat), glutathione peroxidase (Gpx), glutaredoxin (Grx), and thioredoxin (Trx) [16], it relies on mitochondrial Sod1 and Sod2 to efficiently catalyze the conversion of superoxide anions into H 2 O 2 [17], which is subsequently decomposed by Cat into oxygen and water
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Nat Rev Nephrol 22 , 559574 (2026)
