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Am J Psychiatry 166 : 753756

Establish baseline measurements and apply randomization and blinding where possible to minimize bias

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A mitochondrial enzyme CARS2 generates cysteine persulfide from cysteine, which is regarded as one of the major processes for production of persulfides, i.e., molecular species containing more than one sulfur atoms in thiol moiety

The drug is marketed as Zepbound for treatment of overweight/obese patients and Mounjaro for treatment of T2D

Griffin H, Sullivan SC, Barger SW, Phelan KD, Baldini G