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Copper accumulation: While copper is essential, excessive accumulation from multiple sources could theoretically lead to oxidative stress and uniform inflammation, distinct from localized purging

In addition, the N-terminal thioredoxin-like domain of GST, known as the G-site, is responsible for GSH binding 22

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Nucleophilic addition at the electron deficient double bond such as the unsaturated carbonyl compounds, e.g

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doi:10.1056/NEJMoa2502082 Verma S, Bttcher M, Brown P, et al