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The Phe residue that moves between the open and closed conformation is displayed in orange and the residue forming a hydrogen bond with the ligand is displayed in green

Experimental methods Animals Domestic short haired cats (all neutered) were housed at the Pet Health and Nutrition Center (PHNC), Lewisburg, OH, USA, and all procedures were approved by the WALTHAM Animal Welfare and Ethical Review Body and the PHNC Institutional Animal Care and Use Committee