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Methodological caveat: Most human trials use combination formulations published studies often combine GHK-Cu with other actives (e.g., retinoids, vitamin C), making it difficult to isolate GHK-Cus independent contribution

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Interestingly Cu(II) binding to the octarepeat and amyloid regions can induce formation of -sheet secondary structure, characteristic for disease-related fibrillar structures 29,30

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