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Its mechanism of treating RA mainly involves these aspects: anti-inflammation, anti-oxidation, immune regulation, pro-apoptosis, inhibition of angiogenesis, inhibition of osteoclastogenesis, inhibition of fibroblast-like synovial cell proliferation, migration and invasion

Panov AV, Gutekunst C, Leavitt BR, Hayden MR, Burke JR, Strittmatter WJ, et al

10.1007/s00018-020-03454-6 47 FardM.Akhavan-TavakoliM.KhanjaniS.ZareS.EdalatkhahH.ArastehS.et al (2018)

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing sp1 glycosylation