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Adults and children over 16 years: Take 12 tablets daily on an empty stomach

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A randomized controlled trial using a fractional factorial design showed that compared with placebo, the combined supplementation with riboflavin (3 mg/day) and niacin (40 mg/day) for five to six years reduced the prevalence of nuclear cataract but increased the progression of posterior subcapsular cataracts in population affected by multiple nutrient deficiency living in rural China (38)

The ideal long-term storage temperature is below 77f / 25c, nowhere near freezing temperatures