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In addition, reduced total antioxidant status was also observed in type 2 diabetic patients compared to controls and prediabetic patients (136)

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The two-receptor approach is studied because GHRH and GHS-R1a signaling activate complementary but distinct intracellular pathways GHRHR primarily through Gs/cAMP/PKA, GHS-R1a primarily through Gq/PLC/IP3/Ca making the dual-agonist approach a useful research tool for studying somatotrope cell biology comprehensively

doi: 10.1016/S0378-8741(02)00217-9 378 TangWLiSLiuYHuangMTHoCT

Varying definition of cases and controls, laboratory and analytical methods may account for the range of heterogeneity

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