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Series A: Biomed

But the FDA flagged a serious adverse event, including a death, associated with an IV ipamorelin infusion (although it wasnt clear whether the peptide directly caused the participant's death)

10.1016/j.pbb.2014.08.013 227 TiligadaE.KyriakidisK.ChazotP

doi: 10.1016/j.biopha.2020.110439 271 Sa-nguanmooPTanajakPKerdphooSJaiwongkamTWangXLiangGet al

In chronic pain and depression, chronic exposure to stress is a common factor that may produce long-lasting changes (i.e., maladaptive neuroplasticity) in highly sensitive brain areas such as the prefrontal cortex and the hippocampus and in their functional connections, which may underlie the cognitive and behavioral impairments accompanying these conditions (Teffer and Semendeferi, 2012

2F), a diterpenoid chemical ingredient of Salviae miltiorrhizae Radix et Rhizoma , is primarily used to treat cardiovascular and cerebrovascular diseases like atherosclerosis and hypertension due to its anti-inflammatory and endothelial regulatory effects [65,66,67]