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In lipopolysaccharide (LPS)-induced depressive rat models, curcumin pre-treatment reduced neuronal death in the hippocampal CA1 region, likely via the miR-146a-5p/ERK signaling pathway, and was associated with improved synaptic function ( Patients with myocardial infarction (MI) exhibit significantly increased risks of developing depression and anxiety disorders (Sun et al., 2021