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One of the mechanisms by which CerS2 ablation impairs GSIS is through reduction in the level of the protease, PCSK1, responsible for processing proinsulin to functional insulin

Popular methods include the 16/8 method, where you fast for 16 hours and eat within an 8-hour window, and the 5:2 approach, where you eat normally for five days and severely reduce calorie intake for two