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The physiological role of the carotenoid binding remains unknown, but it was speculated that GST P1-1 may catalyze the double-bond isomerization of lutein into zeaxanthin similar to the ketosteroid isomerization discussed below

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Although early findings generated enthusiasm regarding DSIP's potential therapeutic applications, the current body of evidence is limited and often conflicting

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Caffeine and EGCG alleviate high-trans fatty acid and high-carbohydrate diet-induced NASH in mice: Commonality and specificity