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They are non-toxic, self-sterilizing, and improve formulation stability, dissolution, and patient compliance

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Comparison of compounds centers on biological mechanism differences, evidence strength, and observed regeneration outcomes across controlled studies

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(2018) 3:e99123

Confirming normal baseline organ function is a mandatory pretreatment assessment before safely initiating standard disease-modifying antirheumatic drugs (DMARDs) like methotrexate, which is strictly contraindicated in cases of liver disease or severe kidney impairment (Cohen & Mikuls, 2025