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As stated in prior rulemaking (85 FR 58560), generally, the proposed severity level ultimately depends on clinical judgement and, where the data is available, the empirical analysis of the additional resources associated with the secondary diagnosis

doi: 10.1016/j.bbagen.2012.11.020 [DOI] [PubMed] [Google Scholar] 16.Legault J, Carrier C, Petrov P, Renard P, Remacle J, Mirault ME

Padyukov, L

This duality underscores the critical importance of microbial community composition over total amino acid load: a eubiotic microbiome channels tryptophan and methionine toward protective metabolites, whereas dysbiosis skews production toward nephrotoxins

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