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Parrinello, S

& Cashman, J

Additionally, in the context of relatively healthy cohorts like aged or overweight individuals, or even in obese cohorts, NAD + modulation by NR did not correspond to significant changes in mitochondrial homeostasis 314,316,321,335,336

Gut microbes influence the development of central nervous system disorders through epigenetic inheritance

Specifically, NCX4040 treatment led to increased reactive oxygen species (ROS), lipid peroxidation, and activation of ferroptosis-related genes such as CHAC1 , GPX4 , and NOX4