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Neurosci Res

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K.SperottoR

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GSH is synthesized from cysteine, glutamate, and glycine by the ATP-dependent enzyme -glutamyl-cysteine (-GC) ligase (GCL) synthetase, which is composed of the -GC ligase catalytic subunit (GCLC), the -GC modifier subunit (GCLM), and GSH synthetase (GSS) 24

The universal facilitator of GSH breakdown and only know glutathionase enzyme is -glutamyltranspeptidase (GGT) which is located on the outer leaf of the cell's plasma membrane