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US National Institutes of Health, Office of Dietary Supplements

That said, dosages up to 1,200 milligrams per day have been studied with no serious adverse effects reported. However, there isnt much long-term research with high doses of NMN, according to Jillian

Although PUFAs play important physiological roles in promoting growth and development, high PUFA intake can cause fat accumulation, fatty acid oxidation, lipid peroxidation, and even severe injury in the liver [82]

The observed folic acid losses in fortified flour packed in paper bags were most likely due to oxidative degradation

Lizneva et al., 2016)

Therapy continues as long as positive changes occur and is adjusted or discontinued if plateaus develop or goals are achieved