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Oxidative phosphorylation modulators By competitively inhibiting long-chain 3-keto-CoA sulfatase, trimetazidine shifts myocardial metabolism from fatty acid -oxidation to glucose oxidation, thereby optimizing energy production during episodes of ischemia

A central regulator of this process is dynamin-related protein 1 (Drp1), a cytosolic GTPase

As a gut microbiota metabolite, capsiate induces GPX4 expression and inhibits ferroptosis-related intestinal I/R injury [40]

PMID 18312195

R.WinefieldR

To ascertain the role of DMF in activating the TSS pathway, we asked whether DMF could induce the expression of factors suppressed by hemin