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As effects of illness progression may be substantially more non-linear than effects of age, our explicit comparison between patients at contrasting phases of illness, may have been better placed to find such effects

Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., Tomeno, W., Imajo, K., Fujita, K., Yoneda, M., Kataoka, K., Taguri, M., Yamanaka, T., Seko, Y., Tanaka, S., Saito, S., Ono, M., Oeda, S., Eguchi, Y., Aoi, W., Nakajima, A

doi: 10.3390/ijms20246268 53 SahaSet al

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It works by reducing the activity of tyrosinase the enzyme responsible for melanin (skin pigment) production and shifts the balance toward pheomelanin (lighter pigment) instead of eumelanin (darker pigment)

Still, the direction of change is compatible with the broader observation that GHRH-receptor input and GHS-R1a input may cooperate to increase downstream hGH output