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Indeed, HGF amplifies angiogenesis after tMCAO in rats and reduces apoptosis in vitro (Shang et al., 2011)

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However, both mTOR and GSK3 upstream are the negative regulators of autophagy leading to failure of autophagy as in Lafora disease which is an autosomal recessive epilepsy characterized by resistance epilepsy and dementia (Lohi et al