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315 The results showed that, in the OA rat model, liraglutide could activate the PKA/CREB signaling pathway and inhibit the inflammatory response through this pathway, thereby alleviating OA symptoms

While each of these exogenous sources offers distinct advantages (see section 4.2.1), they all encounter the significant challenge of integrating into highly complex adult neuronal networks, which have been meticulously refined during development and are functioning under the straining conditions imposed by neurodegeneration and/or disease at the time of the intervention

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By combining them, researchers can investigate a broader range of biological mechanisms while maintaining consistency across experimental designs